[F41C] SMALLARMS, e.g. PISTOLS OR RIFLES (projecting missiles without use of explosive or combustible propellant charge F41B); ACCESSORIES THEREFOR [5]

Inventor(s): Arthur M. Kelly, III (Fort Worth, TX), Ronald M. Crawford (Granbury, TX) Assignee(s): UNASSIGNED Law Firm: The Iwashko Law Firm, PLLC (no location found) Application No., Date, Speed: 15094898 on 04/08/2016 (977 days app to issue)

Littky is a rebel, a disruptor, an innovator, a trouble maker, and an educator.  They made a movie about him, Newsweek has featured his schools, President Obama talks about his schools and Bill and Melinda Gates gave him millions to grow, refine and scale is model of disruption.

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But sometimes there’s sunshine. On Thanksgiving, I got an email from someone, who turned out to be a radiologist in Boston, politely requesting that a nonprofit that I assist from time to time strike him from their emailed notification list for upcoming meetings; he was on the list by accident.

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The discovery means there are now new puzzles to solve, in terms of how time crystals form in the first place.

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Inventor(s): Hong-Yan Chen (San Jose, CA), Yen-Lung Li (San Jose, CA), Yingda Dong (San Jose, CA) Assignee(s): SanDisk Technologies LLC (Addison, TX) Law Firm: Vierra Magen Marcus LLP (2 non-local offices) Application No., Date, Speed: 15879044 on 01/24/2018 (321 days app to issue)

Here, a ternary heterostructure (Fig. 1), magnetic Fe3O4@GO@TiO2 (denoted as MGT), was developed (10), working as a plasmon-free SERS substrate with high molecular selectivity and stability, as well as a remarkable EF value of up to 8.08 × 106. This notable EF value was found to be mainly attributed to a high-efficiency interfacial CT process between GO and TiO2, which was verified by theoretical calculation and time-resolved diffuse reflectance (TDR) spectroscopic measurements. The present SERS substrate with high sensitivity and selectivity was developed to determine trace biological species, such as programmed cell death receptor ligand 1 (PD-L1, a model molecule), at the single-cell level. PD-L1 and its predominant target, programmed death 1 (PD-1), are two crucial immune checkpoint molecules tightly associated with immune resistance (11), which promote immune evasion and tumor recurrence and metastasis (12). PD-L1 is rarely expressed in regular epithelial tissues but is aberrantly expressed in many cancers, including breast (13), melanoma (14), and renal cell carcinoma (15). Immunotherapy using anti–PD-1 or anti–PD-L1 antibody (Ab) to block the interaction between PD-1 and PD-L1 has shown positive antitumor effects in clinical studies (16). Therefore, the quantitative characterization of PD-L1 expression on the cell surface has become an extremely important subject directly related to the development of diagnostic tools to guide PD-L1–based personalized treatment. A variety of analytical tools for PD-L1 monitoring have been reported during the past few years, such as immunohistochemical detection, mass spectrometry (MS), radiological imaging, flow cytometry, and positron emission tomography (17–21). To give a better understanding of the structural and functional roles that cells play in biological systems, it is necessary to develop a robust tool for the analysis and quantification of the components and metabolites in different individual cells (22). Developing a robust preliminary testing approach that provides reliable and quantitative diagnostic results in real time and in situ PD-L1 monitoring at the single-cell level remains a challenge. Triple-negative breast cancer cells (TNBCs) are types of cancer cells that always exhibit immune evasion and tumor recurrence and metastasis triggered by PD-L1 (12). In this experiment, we successfully used an MGT-based SERS probe to visualize and compare the expression and distribution of PD-L1 on three different kinds of TNBC surfaces at the single-cell level, which helped us to understand how PD-L1 behaves within different breast cancer genomic subtypes.

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But Paki says scattering of ashes on sacred maunga such as Mt Eden, in coastal areas where koiwi (bones) are buried and in areas where food is gathered can cause offence.