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In the psp chiral SFG polarization combination (Fig. 3C), we observe a weak but nonzero chiral signal for the lipid bilayer without channels. This signal is caused by the chiral headgroups of the lipids inducing a chiral-polarized arrangement of water molecules near the polar region of the bilayer. The presence of the 2800-cm−1 stretching band in the chiral spp polarized spectra of the HC8 and S-HC8 channels (Fig. 3D) shows that both channels exhibit a net chiral ordering in the SLB. Although this feature is expected for the S-HC8 channel, this ordering shows that in addition to inducing a dipolar alignment of the water wires, the supported bilayer breaks the symmetry and also induces a net chirality for the HC8 channel (Fig. 3E).

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X-ray crystallography reveals the three-dimensional structure of a molecule, thus making it possible to understand how it works and potentially use this knowledge to subsequently modulate its activity, especially for therapeutic …

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For additional details on the patents granted below, search the USPTO Patent Full-Text and Image Database. 

Inventor(s): Catherine Trent (Allen, TX), Gary A. Frazier (Garland, TX) Assignee(s): RAYTHEON COMPANY (Waltham, MA) Law Firm: Renner, Otto, Boisselle Sklar, LLP (1 non-local offices) Application No., Date, Speed: 15617163 on 06/08/2017 (551 days app to issue)