”The key beneficiary of tourism is generally central government and the key cost bearer of providing facilities for tourism tends to be local government – this mismatch of cost and benefit is the core issue for tourism.”

Jenkins is the consummate American actor. His work ranges from everything from “The Witches of Eastwick” to “Hannah and Her Sisters” to HBO’s "Six Feet Under" to his award winning role in “Olive Kitteridge”

Small business groups last night cautioned the Chancellor against the move, warning it could cause cashflow problems that would push already precarious businesses over the edge.

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The English actress, 35, was absolutely stunning in a gauzy white dress featuring billowing sleeves and a deep V-neckline which perfectly showcased her delicate cleavage.

"The crystals would bend, coil, flex or jump, they would do all sorts of things," Gassensmith said. "That was … interesting."

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Inventor(s): Alexander B. Hirschberg (Dallas, TX), Madeleine Simon (Dallas, TX) Assignee(s): IWEAR HOLDINGS CORP (Dallas, TX) Law Firm: Gearhart Law, LLC (1 non-local offices) Application No., Date, Speed: 29569243 on 06/24/2016 (900 days app to issue)

IN his epic novel, Things Fall Apart, the late Chinua Achebe brought the essence of Igbo adages into very sharp focus. “…

Analysis of crystal structures of HC8 and R-HC8 or S-HC8 further reveals unexpected –C-H—N motifs (dN—HC of 2.7 to 2.8 Å) between two orthogonally disposed imidazole moieties, resulting in the formation of imidazole dimers (Fig. 1D) reminiscent of the structures observed for the His37-quartet proton gate of the Influenza A M2 protein (19, 20). The oxygen atom of each water molecule is simultaneously strongly H-bonded to both imidazole NH groups (dO—H of 1.9 Å) and the vicinal water molecules (dO—H of 1.8 Å) (Fig. 1E). The symmetrical relative disposition of the imidazole dimers was previously observed for other compounds (12, 21) and regulates the water molecules to be statistically restricted to two orientations of opposite chiralities in such a way that the water wires within the same channel present a unique dipolar orientation. Here, on the other hand, the relative asymmetric structures of the imidazole dimers in the self-assembled HC8 and R-HC8 or S-HC8 compounds determine a unique dipolar orientation of the water molecules comprising a crystallographic 100% occupancy of both water H atoms bonded to N-imidazoles and neighboring water molecules (Fig. 1E). Each individual I-quartet channel is supramolecularly chiral and contains dipolar water wires oriented in one direction. The overall structure of achiral compound HC8 is centrosymmetric, so that the water wires of the opposite water dipolar orientations are present in successive enantiomeric water-filled channels, separated by water-free I-quartets (Fig. 1F). In contrast, the noncentrosymmetric structures of chiral compounds R-HC8 and S-HC8 show a unique dipolar orientation for all water-filled I-quartet channels (Fig. 1G).

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