Inventor(s): Ian A. Hill (Plano, TX) Assignee(s): Oz-Post International, LLC (Richardson, TX) Law Firm: Foley Lardner LLP (Local + 13 other metros) Application No., Date, Speed: 15168649 on 05/31/2016 (924 days app to issue)

Dharmarwardana conducted a new set of experiments in which she glued down one end of the crystal to a glass cover slip and placed the slip on a hot plate.

Abstract: Devices, systems, and methods include controls for on-die termination (ODT) and data strobe signals. For example, a command to de-assert ODT for a data pin (DQ) during the read operation. An input, such as a mode register, receives an indication of a shift mode register value that corresponds to a number of shifts of a rising edge of the command in a backward or a falling edge in a forward direction. A delay chain delays the appropriate edge of received command the number of shifts in the corresponding direction to generate a shifted edge command signal. Combination circuitry then combines a falling edge command signal with a shifted rising edge command signal to form a transformed command.

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At Americhem Inc. in Cuyahoga Falls, Ohio, 2018 has been a strong year, with good growth in health care, transportation and film and sheet. The firm’s custom manufacturing approach is focused on helping customers solve problems, according to CEO Matthew Hellstern. “We add value beyond supplying materials,” he said.

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Abstract: A low dynamic resistance, low capacitance diode of a semiconductor device includes a heavily-doped n-type substrate. A lightly-doped n-type layer 1 micron to 5 microns thick is disposed on the n-type substrate. A lightly-doped p-type layer 3 microns to 8 microns thick is disposed on the n-type layer. The low dynamic resistance, low capacitance diode, of the semiconductor device includes a p-type buried layer, with a peak dopant density above 110[superscript]17 [/superscript]cm[superscript]3[/superscript], extending from the p-type layer through the n-type layer to the n-type substrate. The low dynamic resistance, low capacitance diode also includes an n-type region disposed in the p-type layer, extending to a top surface of the p-type layer.

The Lime Crime Venus III Pressed Powder Palette, an offshoot of the beauty brand’s popular Venus Palette, features two purple hues that have duochrome shifts. Beam, the lighter one, shifts to pink while Paradise transforms into a cobalt when the light hits it.

Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Vat violet 1 Market @ http://industryresearch.co/global-and-chinese-vat-violet-1-industry-2018-market-research-report-13132518

The MGT substrate with high reproducibility, sensitivity, and selectivity was then developed as an immunoassay SERS probe (MGT-Abs-CuPc) through the immobilization of the PD-L1 Abs and CuPc for PD-L1 analysis on TNBC surfaces (Fig. 5A). As shown in fig. S5A, upon the introduction of CuPc molecules to MGT, the UV-vis spectrum exhibits two peaks at 620 and 690 nm, which correspond to the adsorption of CuPc. After the immobilization of Abs to MGT, we observed an additional peak at ~260 nm, which should be attributed to adsorption of Abs. All these three additional peaks show the successful fabrication of the MGT-Abs-CuPc nanoprobe. To further confirm Abs conjugation to the nanostructures, we performed SDS–polyacrylamide gel electrophoresis (PAGE) imaging of MGT, Abs, and Abs-modified MGT (MGT-Abs). SDS-PAGE is a powerful analytical technique for protein identification in complex biological samples and has been widely used in biological studies for decades. As shown in fig. S5B, MGT-Abs [fig. S5B (III)] was higher than both MGT [fig. S5B (I)] and Abs [fig. S5B (II)], indicating the different molecular weights: MGT-Abs > MGT > Abs. SDS-PAGE imaging in fig. S5B (I to III) definitively showed the successful conjugation between the nanostructure and Abs. In addition, we also carried out FTIR spectroscopy (fig. S5C) to investigate the conjugation. Compared to MGT, MGT-Abs showed an additional infrared band assigned to the C–N stretching vibration at 1400 cm−1 and the C=O stretching vibration at 1620 cm−1. These two additional peaks were attributed to the formation of an amide bond at the interface between MGT and Abs. Both SDS-PAGE images and FTIR results revealed that Abs has been successfully conjugated to the nanostructures. We carried out confocal imaging to verify the recognition ability of MGT-Abs to the PD-L1 protein. We conducted three parallel experiments, which are shown in fig. S5 (D to G). No fluorescence signal was obtained after the coincubation of MGT and Cy5-labeled PD-L1. Moreover, before incubating with Cy5-labeled PD-L1, MGT-Abs also showed weak fluorescence. However, after the incubation with Cy5-labeled PD-L1, confocal images exhibited a bright fluorescence signal, indicating the high affinity and recognition ability of MGT-Abs to the PD-L1 protein. We incubated the developed probe with high SERS activity with TNBCs to quantify the PD-L1 expression on the surface of different TNBCs (Fig. 5A) using Raman spectroscopy. Temperature and incubation time are two important factors that determine the overall SERS signals. As shown in fig. S5 (H and I), the maximum SERS response was achieved at 37°C and 60 min. The amount of CuPc and Abs immobilized on MGT was another important experimental parameter. As the concentration of CuPc and Abs progressively increased, we observed the Raman peak at 1530 cm−1 to first increase and then decrease after the concentration reached 10 mM for CuPc and 100 μM for Abs, indicating that the optimal concentration of CuPc is 10 mM, while that of Abs is 100 μM (fig. S5, J and K). Moreover, we examined the cytotoxicity of the MGT-Abs-CuPc probe with a 3-(4,5-dimethylthiazol-2-yl)-2-diphenyltetrazolium bromide assay. As a result, the variability of HCC38, MDA-MB-231, and MCF-7 cells remained approximately 98% (15 μM, 120 min; fig. S6), indicating the low cytotoxicity of the probe. After optimizing experimental conditions and assessing biocompatibility, we conducted three parallel experiments to evaluate the PD-L1 expression levels on three different types of TNBC (HCC38, MCF-7, and MDA-MB-231) surfaces. HCC38 cells were first used as model cells. As shown in Fig. 5B, Raman intensity increased with an increasing number of cells captured on the silicon foil. The intensity of the Raman peak at 1530 cm−1 was used to reflect the amount of the MGT-Abs-CuPc probe attached to the cell surface. The intensity of the Raman peak (I) was proportional to the logarithmic value of captured cancer cells (N) in the range from 5 × 102 to 5 × 105 cells (R = 0.990, n = 7; Fig. 5C), which was consistent with the kinetics mechanism of the antigen-Abs reaction in the Abs excess zone (fig. S7A). The linear regression is shown in Eq. 1

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North Texas is a big place, with plenty of opportunities. So, we’re constantly on the lookout for contests and competitions, award ceremonies, and available grants our innovators can apply for. …