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Surface-enhanced Raman scattering (SERS) has been a promising analytical technique for the detection of trace species because of its remarkable advantages, namely, it is sensitive, it is nondestructive, it has a quick response time, and it provides unique information on the species (1–3). Studies on noble metal nanostructures, such as Au, Ag, and Cu, indicate that the tremendous electromagnetic field enhancement at the hotspots greatly increases the sensitivity of SERS (4). However, the SERS effect based on electromagnetic field enhancement has no selectivity for Raman reporters, resulting in complicated signal outputs generated by unexpected interactions (5). Recently, another mechanism, chemical enhancement mechanism (CM), which is related to the formation of charge transfer (CT) states between the adsorbed molecules and the nanoparticles (NPs) (6), has attracted more attention. Compared with SERS, which is based on electromagnetic field mechanism, this unique method always demonstrates high molecule selectivity. Most substrates based on CM show stable and reproducible SERS signals without agglomeration, which is different from those obtained from noble metals. Moreover, the CM-based substrate exhibits good biocompatibility without cytotoxic outcomes. Thus, various new materials have been developed to investigate CT in plasma-free SERS, such as graphite oxide (GO) and semiconductor materials (7). However, only 10 to 100 enhancements have been achieved by these materials (8, 9), limiting their potential applications for reliable quantitative detection in biological and biomedical analysis and diagnosis. Accordingly, low enhancement factor (EF) values prevent further applications of CM-based SERS substrates.

You may want to use the enzymes a few times, and then use a solvent like rubbing alcohol to clean whatever’s left. If you’re concerned about applying a solvent to a delicate item, use a weaker solution available at drugstores, or dilute your rubbing alcohol with one part water to one part alcohol.

[G06F] ELECTRIC DIGITAL DATA PROCESSING (computer systems based on specific computational models G06N)

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• Urgent action is needed to develop new approaches and to improve existing tools to protect the country’s environment and economy.

Once dubbed the Godfather of Ethics Reform, West has been the driving force in reforming governmental ethics for three decades in Rhode Island. 

32-bit era nostalgic and gadget enthusiast Tom has been writing for Eurogamer and Digital Foundry since 2011. His favourite games include Gitaroo Man, F-Zero GX and StarCraft 2.

[G01R] MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J 3/12)

When you spot your first gray hairs, step away from the tweezers. While it may be tempting to pull out a silver strand or two, doing so can actually get in the way of your gray greatness and make your hair appear thinner. "Plucking, in some cases, can cause inflammation of the root of the hair, leading to damage to the follicle, helping the hair look like it’s coming in thinner," says Zeichner. "Most of the time, plucking does not truly thin out the hair, but it appears thinner as it grows in because a new hair is formed with a thin edge.

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The latest original film to land on Netflix is the Saudi-directed romantic comedy Nappily Ever After.