Inventor(s): Harish N. Venkata (Allen, TX), Mansour Fardad (Allen, TX) Assignee(s): Micron Technology, Inc. (Boise, ID) Law Firm: Dorsey Whitney LLP (6 non-local offices) Application No., Date, Speed: 14944622 on 11/18/2015 (1119 days app to issue)

A decades-old mystery of why a naturally-occurring organic crystal fluoresces blue under ultra-violet light, yet when grown under laboratory conditions fluoresces with an intense green colour, has been solved by scientists …

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Inventor(s): Robert M. Boyd (Flower Mound, TX) Assignee(s): NIKE, Inc. (Beaverton, OR) Law Firm: Banner Witcoff, Ltd. (3 non-local offices) Application No., Date, Speed: 15225143 on 08/01/2016 (862 days app to issue)

Abstract: A method includes acquiring magnetic data from a magnetometer, processing the magnetic data to perform robust calibration, and generating optimum calibration parameters using a calibration status indicator. To that end, the method includes generating a calibration status indicator as a function of time elapsed since a last calibration and variation in total magnetic field in previously stored magnetic data, detecting anomalies, and extracting a sparse magnetic data set using comparison between the previously stored magnetic data and the magnetic data. Calibration parameters are generated for the magnetometer using a calibration method as a function of the magnetic data set. The calibration parameters are stored based on performing a validation and stability check on the calibration parameters, and weighted with the previously stored calibration parameters to produce weighted calibration parameters. Calibration settings are generated as a function of the weighted calibration parameters, if the weighted calibration parameters were produced.

Elastomeric gel body gasket having a substantially incompressible skeleton, a method of making and using the same Patent No. 10150555 

In the past few years, his work at Brown has focused on neural and cognitive sciences and has been “working towards an understanding of memory and other brain functions, and thus formulating a scientific model of how the human mind works.”  

Mike Cherry, national chairman of the Federation of Small Businesses, said: ‘At a time of spiralling costs and persistent uncertainty, a lowering of the VAT threshold is the last thing our entrepreneurs need.’

So a highly-charged public reaction to the council’s planned bylaw and code of practice for cemeteries and crematoria was inevitable once the Funeral Directors Association raised the alarm.

In addition, the decrease in intensity (ΔI) does not respond to the change in the amount of PD-L1 (m; Fig. 5J). It indicated that MCF-7 cells express few PD-L1 on the surface (Fig. 5, E to J). The average number of PD-L1 on each captured MDA-MB-231 cell was calculated to be ~2973, which was more than twofold that on each HCC38 cell. Conversely, negligible expression of PD-L1 was shown on the MCF-7 cell surface. Consequently, the expression of PD-L1 on three types of TNBCs is summarized in Fig. 5K: MDA-MB-231 > HCC38 >> MCF-7. This result suggests that the MDA-MB-231 cells might be more sensitive to the PD-L1 Abs treatment than HCC38 and MCF-7 cells. Moreover, compared with MCF-7, which belongs to the subtype Luminal in the American Type Culture Collection breast cancer cell line, HCC38 and MDA-MB-231 exhibit higher PD-L1 expression on cell surfaces. Both HCC38 and MDA-MB-231 belong to Basal B, not Luminal. Therefore, the quantitative characterization of PD-L1 expression on different subtypes of cell surfaces has become an extremely important subject directly related to the development of diagnostic tools for personalized treatment. The high expression of PD-L1 on cell surfaces of HCC38 and MDA-MB-231 indicated that Basal B subtype TNBCs always express more PD-L1 on cell surfaces, which means that this type of TNBC may be more sensitive to PD-L1 treatment than Luminal TNBCs. The expression of PD-L1 in MDA-MB-231 is slightly higher than that in HCC38. Thus, MDA-MB-231 cells may be more sensitive to PD-L1 treatment. In addition, within the same subtype of TNBCs, different cell lines express different amounts of PD-L1 and exhibit different responses to the stimulation of interferon-γ (IFN-γ), which may relate to the different activities of signal pathways in different cell lines, such as JAK/STAT, MEK/ERK, and PI3K/AKT signaling. It has been reported that high PD-L1 basal cell lines have lower expression of IRF2BP2 and higher STAT1 levels, compared with low PD-L1–expressing cell lines (37). A direct comparison for the PD-L1 expression among three types of TNBC cell lines provided direct evidence for further evaluation of the mechanism about the cell signal pathway.

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